| Autor: |
Galindo RC; Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain., Doncel-Pérez E, Zivkovic Z, Naranjo V, Gortazar C, Mangold AJ, Martín-Hernando MP, Kocan KM, de la Fuente J |
| Jazyk: |
angličtina |
| Zdroj: |
Developmental and comparative immunology [Dev Comp Immunol] 2009 Apr; Vol. 33 (4), pp. 612-7. Date of Electronic Publication: 2008 Nov 28. |
| DOI: |
10.1016/j.dci.2008.11.002 |
| Abstrakt: |
The tick protective antigen, subolesin, is a regulatory protein involved in the control of multiple cellular pathways. Subolesin is evolutionary conserved in invertebrates and vertebrates with sequence homology to akirins, a recently renamed group of proteins that were proposed to function as transcription factors in Drosophila and mice. The objective of this research was to provide evidence of the sequence and functional homology between tick subolesin and akirins. The phylogenetic analysis of subolesin and akirins showed that they are evolutionary conserved. The effect of subolesin and akirin2 knockdown was compared in adult ticks and mice, respectively. The results demonstrated that tick subolesin is an ortholog of insect and vertebrate akirins and suggested that these proteins function in the regulation of NF-kappaB-dependent and independent expression of signal transduction and innate immune response genes. These results suggest that these proteins have an important role in host-pathogen interactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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