| Autor: |
Furmanczyk PS; University of Washington, Department of Pathology, Seattle, WA 98195-6100, USA. pfurman@u.washington.edu, Hughes SR, Walsh JS, Bass J, McFarlane JR, Argenyi ZB |
| Jazyk: |
angličtina |
| Zdroj: |
The American Journal of dermatopathology [Am J Dermatopathol] 2008 Dec; Vol. 30 (6), pp. 600-3. |
| DOI: |
10.1097/DAD.0b013e3181834acd |
| Abstrakt: |
The occurrence of primary cutaneous ganglioneuroma is rare. We report 2 separate cases of primary cutaneous ganglioneuroma, both of which are associated with prominent overlying hyperkeratosis. The first case was in a 38-year-old woman with overlying verrucous keratosis. The second case was in a 93-year-old man with epidermal changes reminiscent of a seborrheic keratosis. Histologically, both lesions were composed of a proliferation of hyperplastic nerve fibers with spindled Schwann cells and axons with intermingled ganglion cells. Immunohistochemistry for neurofilament highlighted nerve fascicles; S100 protein displayed the associated Schwann cells, and neuron-specific enolase stained the interspersed ganglion cells. Variation in immunohistochemical staining was present between the 2 cases. A review of the literature demonstrates variable immunohistochemical staining of ganglion and Schwann cells in prior cases. Familiarity with these findings is important in establishing a diagnosis. The significance of the associated hyperkeratosis remains speculative. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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