| Autor: |
Gunn SR; Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Bolla AR, Barron LL, Gorre ME, Mohammed MS, Bahler DW, Mellink CH, van Oers MH, Keating MJ, Ferrajoli A, Coombes KR, Abruzzo LV, Robetorye RS |
| Jazyk: |
angličtina |
| Zdroj: |
Leukemia research [Leuk Res] 2009 Sep; Vol. 33 (9), pp. 1276-81. Date of Electronic Publication: 2008 Nov 21. |
| DOI: |
10.1016/j.leukres.2008.10.010 |
| Abstrakt: |
We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL. Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34 Mb up to approximately 1 Mb. The minimally deleted region included the ZNF280A, ZNF280B, GGTLC2, and PRAME genes. Quantitative real-time PCR revealed that ZNF280A, ZNF280B, and PRAME mRNA expression was significantly lower in the 22q11 deletion cases compared to non-deleted cases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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