| Autor: |
Kulinich TM; Russian Research Center of Roentgenology and Radiology, Russian Medical Technologies, Moscow. sobral@mail.ru, Kharchenko VP, Filyasova EI, Shishkin AM, Bozhenko VK |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Jan; Vol. 145 (1), pp. 37-40. |
| DOI: |
10.1007/s10517-008-0015-8 |
| Abstrakt: |
Properties of chimeric peptides containing cell-penetrating sequences and pl6INK4a and E2F fragments were studied in vitro on immurtal cultures of human cells. Both sequences exhibit cytostatic activity. The peptide containing fragment p16INK4a inhibited proliferation during the G0/G1 stage of the cell cycle, while sequence E2F suppressed proliferation in S phase. Both sequences exhibit cytotoxic properties and can induce apoptosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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