[Therapeutic effect of mitomycin C in the immediate postoperatory in patients with low-risk non-muscle-invasive bladder tumours].

Autor:	Jalón Monzón A; Servicio de Urología, Hospital Universitario Central de Asturias. ajalonm@hotmail.com, Fernández Gómez JM, Escaf Bramada S, Alvarez Múgica M, García Rodríguez J, Regadera Sejas FJ
Jazyk:	Spanish; Castilian
Zdroj:	Actas urologicas espanolas [Actas Urol Esp] 2008 Sep; Vol. 32 (8), pp. 811-20.
DOI:	10.1016/s0210-4806(08)73940-8
Abstrakt:	Introduction: Bladder cancer is a disease with a high prevalence due to its recurrence rate. Transurethral resection of the bladder (TURB) is the treatment in initial stages. Nevertheless, a high percentage of non-muscle-invasive tumors treated will have a recurrence 1-2 years afterwards. Adjuvant quemotherapy or immunotherapy after TURB has been administered in order to decrease the rate of recurrence and to prevent progression. Patients and Methods: A prospectived, controlled and randomized study was performed. We included 100 patients with non-muscle-invasive and bladder tumors the low grade. All patients had initially a TURB performed and were randomized to either receive or not a single dose mitomycin C (MMC) in the immediate postoperatory. Results: All low grade tumors was less than 3 cm. Mean follow-up was 26.43 +/- 7.65 months. MMC was administered in 49 patients, of these, 67.3% had no recurrence and 32.7% had a non-muscle-invasive recurrence. Of the 51 patients in the non mitomycin, 51% had no recurrence while 47% had a non-muscle-invasive recurrence, and 2% had a muscle-invasive progression. We found significantly differences in time to recurrence among the two groups. Summary: We found a greater time to recurrence in the group of single dose adjuvant MMC being this difference statistically significantly when comparing with the other group.
Databáze:	MEDLINE
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