| Autor: |
Little PF; University Hall, National University of Singapore, 119077 Singapore. Peter.Little@nus.edu.sg, Williams RB, Wilkins MR |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in biotechnology [Trends Biotechnol] 2009 Jan; Vol. 27 (1), pp. 5-10. Date of Electronic Publication: 2008 Nov 17. |
| DOI: |
10.1016/j.tibtech.2008.10.002 |
| Abstrakt: |
The past decade has seen an explosion of variation data demonstrating that diversity of both protein-coding sequences and of regulatory elements of protein-coding genes is common and of functional importance. In this article, we argue that genetic diversity can no longer be ignored in studies of human biology, even research projects without explicit genetic experimental design, and that this knowledge can, and must, inform research. By way of illustration, we focus on the potential role of genetic data in case-control studies to identify and validate cancer protein biomarkers. We argue that a consideration of genetics, in conjunction with proteomic biomarker discovery projects, should improve the proportion of biomarkers that can accurately classify patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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