| Autor: |
Kuiper SM; Molecular Materials, Institute for Molecules and Materials, University of Nijmegen, Toernooiveld 1, Nijmegen, Gelderland, Netherlands 6500 GL., Nallani M, Vriezema DM, Cornelissen JJ, van Hest JC, Nolte RJ, Rowan AE |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2008 Dec 07; Vol. 6 (23), pp. 4315-8. Date of Electronic Publication: 2008 Oct 15. |
| DOI: |
10.1039/b811196k |
| Abstrakt: |
Polystyrene(40)-b-poly(isocyanoalanine(2-thiophen-3-yl-ethyl)amide)(50) (PS-PIAT) polymersomes have the unique property of being sufficiently porous to allow diffusion of small (organic) substrates while retaining large biomolecules such as enzymes inside. Herein we report on the encapsulation and protection of glucose oxidase (GOx) and horse radish peroxidase (HRP) in PS-PIAT polymersomes and the successful employment of these functionalised nanoreactors in a cascade reaction. The demonstrated concept allows for further application in other enzymatic cascade reactions, bio-organic hybrid systems and biosensing devices. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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