Susceptibility to hyperglycemia in patients with chronic kidney disease.
| Autor: | Shehab-Eldin W; Department of Internal Medicine, Faculty of Medicine, Menofia University, Cairo, Egypt., Zaki A, Gazareen S, Shoker A |
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| Jazyk: | angličtina |
| Zdroj: | American journal of nephrology [Am J Nephrol] 2009; Vol. 29 (5), pp. 406-13. Date of Electronic Publication: 2008 Nov 07. |
| DOI: | 10.1159/000171379 |
| Abstrakt: | Background: Patients with chronic kidney disease (CKD) are susceptible to hyperglycemia. Aim: To study the prevalence of pre-diabetes in CKD patients and determine the contribution of insulin resistance (IR) versus beta-cell dysfunction in patients with CKD. Methods: 45 consecutive nondiabetic CKD patients and 40 healthy subjects were included. Patients were divided into a normoglycemic (NG) and a pre-diabetic (PDM) group. IR was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function was assessed by proinsulin/insulin ratio and beta-cell%. Results: The prevalence of PDM was 40%. The prevalence of high HOMA-IR was 22.2 and 77.8% in the NG and PDM groups. Compared to NG patients, the PDM group showed higher fasting plasma glucose, HOMA-IR, insulin, and proinsulin, while the prevalence of beta-cell dysfunction of 22.2% was lower than the 37% present in the NG group. Conclusion: Increased IR, rather than beta-cell dysfunction, is the primary mechanism of PDM in CKD patients. (Copyright (c) 2008 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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