| Autor: |
Stefan van Staden RI; Department of Chemistry, University of Pretoria, Pretoria, South Africa. Raluca.Stefan@chem.up.ac.za, Rat'ko AA |
| Jazyk: |
angličtina |
| Zdroj: |
Talanta [Talanta] 2006 Jul 15; Vol. 69 (5), pp. 1049-53. Date of Electronic Publication: 2006 Jan 19. |
| DOI: |
10.1016/j.talanta.2005.12.022 |
| Abstrakt: |
Two enantioselective, potentiometric membrane electrodes based on alpha- and gamma-cyclodextrins were proposed for the assay of R-baclofen. The slopes of the electrodes were 59.50 and 51.00 mV/pR-baclofen for alpha- and gamma-cyclodextrin-based electrodes, respectively. The detection limits of the proposed electrodes were 7 x 10(-9)mol l(-1) for alpha-cyclodextrin-based electrode and 1.44 x 10(-10)mol l(-1) for gamma-cyclodextrin-based electrode. The enantioselectivity was determined over S-baclofen. The proposed electrodes can be employed for the assay of R-baclofen raw materials and its pharmaceutical formulation, Norton-Baclofen tablets. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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