| Autor: |
Dinesh ND; Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India., Nagaraja P, Made Gowda NM, Rangappa KS |
| Jazyk: |
angličtina |
| Zdroj: |
Talanta [Talanta] 2002 Jun 10; Vol. 57 (4), pp. 757-64. |
| DOI: |
10.1016/s0039-9140(02)00097-8 |
| Abstrakt: |
Two simple and sensitive extractive spectrophotometric methods for the determination of sildenafil citrate (SC) are proposed. The methods are based on the formation of ion-association complexes of sildenafil citrate with bromocresol green (BCG, method A) and with chromoxane cyanine R (CCR, method B) in aqueous acidic buffer. The complex species, extractable to chloroform phase, were quantitatively measured at 415 and 460 nm for methods A and B, respectively. Beer's law was obeyed in the SC concentration range 1.25-25 mug ml(-1) with a limit of detection 0.16 mug ml(-1) and 1.5-60 mug ml(-1) with a limit of detection 0.18 mug ml(-1), respectively, for methods A and B. The methods have been successfully applied to the analysis of bulk drug and its tablets. No interference was observed from common pharmaceutical adjuvants. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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