| Autor: |
Sands MF; VA Western New York Healthcare System, Buffalo, NY 14215, USA. mfsands@buffalo.edu, Ohtake PJ, Mahajan SD, Takyar SS, Aalinkeel R, Fang YV, Blume JW, Mullan BA, Sykes DE, Lachina S, Knight PR, Schwartz SA |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2009 Feb; Vol. 130 (2), pp. 186-98. Date of Electronic Publication: 2008 Oct 26. |
| DOI: |
10.1016/j.clim.2008.08.029 |
| Abstrakt: |
Matrix metalloproteinases (MMPs) modulate development, inflammation, and repair in lungs. Tissue inhibitors of MMPs (TIMPs) interact with MMPs, controlling the intensity and nature of the response to injury. Absence of MMP-9, -2, and -8 activities is associated with altered lung inflammation during allergic sensitization. To test the hypothesis that the absence of TIMP-1 enhances allergic lung inflammation, airway hyperreactivity (AHR), and lung remodeling in asthma, we studied TIMP-1 null (TIMP-1 KO) mice and their WT controls using an ovalbumin (OVA) asthma model. TIMP-1 KO mice, compared to WT controls, developed an asthma phenotype characterized by AHR, pronounced cellular lung infiltrates, greater reduction in lung compliance, enhanced Th2 cytokine mRNA and protein expression, and altered collagen lung content associated with enhanced MMP-9 activity. Our findings support the hypothesis that TIMP-1 plays a protective role by preventing AHR and modulating inflammation, remodeling, and cytokine expression in an animal model of asthma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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