| Autor: |
van de Veerdonk FL; F.veerdonk@aig.umcn.nl, Netea MG, Jansen TJ, Jacobs L, Verschueren I, van der Meer JW, Kullberg BJ |
| Jazyk: |
angličtina |
| Zdroj: |
Immunobiology [Immunobiology] 2008; Vol. 213 (8), pp. 613-20. Date of Electronic Publication: 2008 Jun 26. |
| DOI: |
10.1016/j.imbio.2008.05.002 |
| Abstrakt: |
The role of Toll-like receptor-9 (TLR9) in the recognition of Candida albicans and anti-Candida host defense was investigated in a murine model of disseminated candidiasis and in human peripheral blood mononuclear cells (PBMC). Blocking TLR9 by a specific inhibitor of human TLR9 or stimulation of cells isolated from TLR9-deficient (TLR9-/-) mice resulted in a 20-30% reduction in cytokine production induced by C. albicans. However, this defect was not accompanied by differences in mortality and organ fungal growth between TLR9-/- and TLR9+/+ mice. In conclusion, TLR9 is a pathogen-recognition receptor for C. albicans, and TLR9 is involved in the induction of cytokines in response to C. albicans. However, the cytokine defect in TLR9-/- mice is compensated by alternative pathways, and the TLR9-dependent pathway seems to be redundant in the disseminated candidiasis model in mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect