| Autor: |
Araújo FM; Instituto de Pesquisa René Rachou-Fiocruz, Belo Horizonte, MG, Brasil. araujo@cpqrr.fiocruz.br, Sonoda IV, Rodrigues NB, Teixeira R, Redondo RA, Oliveira GC |
| Jazyk: |
angličtina |
| Zdroj: |
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2008 Sep; Vol. 103 (6), pp. 611-4. |
| DOI: |
10.1590/s0074-02762008000600018 |
| Abstrakt: |
Sequence variation among different hepatitis C virus (HCV) isolates has adaptive significance and reflects the modes and intensities of selection mechanisms operating on the virus. In this work, we sought to investigate using classical population genetics parameters, the genetic variability of HCV genotype 1 using the 5' UTR and NS5A regions from treatment non-responding and responding groups of patients. Both regions showed low genetic variability and the 5' UTR showed neutral deviation. No differences were observed in the nonsynonymous/synonymous nucleotide substitution ratio among groups for NS5A. The analysis of molecular variance test of the 5' UTR region showed an 11.94% variation among groups. Phylogenetic analysis showed no correlation between sequence variations and therapeutic responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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