| Autor: |
Almeida SM; Clinical Pathology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. sergio.ma@pop.com.br, Cunha DS, Yamada E, Doi EM, Ono M |
| Jazyk: |
angličtina |
| Zdroj: |
Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2008 Sep; Vol. 66 (3B), pp. 720-4. |
| DOI: |
10.1590/s0004-282x2008000500022 |
| Abstrakt: |
Several markers have been studied for their ability to make the CNS infiltration diagnosis earlier and more precise; previous studies showed that CSF ferritin concentrations were higher in patients with malignant invasion of CNS. The objective was to determine the importance of CSF ferritin as a biomarker for the diagnosis of CNS neoplastic infiltration. This study is based on 93 CSF samples, divided into five groups: malignant cells present (n13); malignant cells not present (n26); inflammatory neurological diseases (n16); neurocysticercosis (n20); acute bacterial meningitis (n18). CSF ferritin values were determined by micro particle enzyme immunoassay. CSF ferritin level (mean+/-SD) in the group with neoplastic cells in the CSF was 42.8+/-49.7 ng/mL, higher than in the other groups (p<0.0001). We conclude that CSF ferritin with the cut off 20 ng/mL could be an adjuvant biomarker to the diagnosis of CNS malignant infiltration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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