| Autor: |
Lowry PA; Department of Internal Medicine (Hematology/Oncology), University of Virginia Health Sciences Center, Charlottesville 22908., Zsebo KM, Deacon DH, Eichman CE, Quesenberry PJ |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental hematology [Exp Hematol] 1991 Oct; Vol. 19 (9), pp. 994-6. |
| Abstrakt: |
We have previously defined a subset of High Proliferative Potential Colony Forming Cells (HPP-CFC), derived from murine marrow purified for early progenitors expressing the Stem Cell Antigen (SCA+) and lacking terminal lineage markers (Lin-), which are responsive to multiple cytokines in combination. Stem Cell Factor (SCF), a multipotent growth factor which is the ligand for c-kit, synergizes with these multiple factor combinations to increase colony number and size. SCF is thus a potent mitogen with direct action on early hematopoietic progenitor cells. These data are consistent with a model of stromal control of hematopoiesis via elaboration of multiple cytokines in locally high concentration, with SCF playing a central role. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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