| Autor: |
Bergman RK, Munoz JJ |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 1977 Jan; Vol. 15 (1), pp. 72-7. |
| DOI: |
10.1128/iai.15.1.72-77.1977 |
| Abstrakt: |
CFW mice given submicrogram doses of endotoxins intravenously became highly susceptible to the lethal effects of 0.5 mg of histamine given intraperitoneally 1 to 2 h later. The histamine-sensitizing effects of the endotoxins were transitory and disappeared within 6 to 8 h. L-Epinephrine administered intravenously immediately after histamine challenge protected mice from death, but aterenol and isoproterenol were ineffective. The histamine-sensitizing effect in endotoxins was precipitated by anti-endotoxin sera with a concomitant eightfold loss in activity. However, dissociation of the immune complex in 0.25 M acetic acid fully restored histamine-sensitizing activity. The transitory nature of the hypersensitivity produced by endotoxin and the high heat resistance of the active material prove that it is different from the histamine-sensitizing effects of pertussigen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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