| Autor: |
Cheung M; GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. mui.h.cheung@gsk.com, Harris PA, Badiang JG, Peckham GE, Chamberlain SD, Alberti MJ, Jung DK, Harris SS, Bramson NH, Epperly AH, Stimpson SA, Peel MR |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Oct 15; Vol. 18 (20), pp. 5428-30. Date of Electronic Publication: 2008 Sep 12. |
| DOI: |
10.1016/j.bmcl.2008.09.040 |
| Abstrakt: |
A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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