Synthesis and biological evaluation of 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents.

Autor: Reddy PB; Department of Synthetic Chemistry, Indian Institute of Integrative Medicine, Jammu-Tawi 180001, India., Agrawal SK, Singh S, Bhat BA, Saxena AK, Kumar HM, Qazi GN
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2008 Sep; Vol. 5 (9), pp. 1792-802.
DOI: 10.1002/cbdv.200890168
Abstrakt: A series of novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu(I)-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9e, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713 cell lines.
Databáze: MEDLINE
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