[The labeling index of parenchymal and stromal tumor cells--an index of radiosensitivity and prognosis of laryngeal cancer].
| Autor: | Solov'eva LP |
|---|---|
| Jazyk: | ruština |
| Zdroj: | Meditsinskaia radiologiia [Med Radiol (Mosk)] 1991; Vol. 36 (7), pp. 14-6. |
| Abstrakt: | Biopsy specimens were taken from 130 laryngeal cancer patients and investigated before treatment. Autoradiography with 3H-thymidine was used to determine the labeling index (LI) of parenchymal cells and tumor stroma. Squamous cell carcinoma was diagnosed in all the cases. Altogether 41 patients were irradiated at a total focal dose of 32-40 Gy and underwent surgery. A full course of radiotherapy at a total dose of 52-60 Gy was given to 89 patients, however recurrences were detected in 38. Comparison of the therapeutic results and indices of proliferative activity of tumor cells has shown: 1. interrelationship of Ll of parenchymal cells and LlI of tumor stromal cells; 2. a tendency to correlation was revealed between indices of LI of parenchymal and stromal cells and a stage of disease; 3. correlation between a degree of a decrease in LI of parenchymal cells and completeness of tumor regression in the course of therapy was shown; 4. LI of stromal cells in the patients' tumors with resumption of tumor growth was lower (0.8) than in patients without resumed growth. |
| Databáze: | MEDLINE |
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