| Autor: |
Sandoval WN; Genentech Inc., Department of Protein Chemistry, 1 DNA Way, MS 413A, South San Francisco, CA 94080, USA., Pham VC, Lill JR |
| Jazyk: |
angličtina |
| Zdroj: |
Drug discovery today [Drug Discov Today] 2008 Dec; Vol. 13 (23-24), pp. 1075-81. Date of Electronic Publication: 2008 Nov 07. |
| DOI: |
10.1016/j.drudis.2008.08.007 |
| Abstrakt: |
Over the past 30 years, biotechnology has evolved as a multibillion dollar industry. A large sector of this industry is associated with translating human genetic information to discover, develop and commercialize bio-therapeutics. A broad range of disciplines across the Life Sciences is necessary for the selection of bio-molecules as biotechnological drug targets. Global and targeted proteomic approaches, as well as in-depth characterization of select proteins, are part of the process necessary for drug discovery and validation. Recently, microwave-assisted proteomic methodologies have emerged as useful tools for increasing the bio-catalysis and, therefore, throughput of analytical processes associated with protein characterization. Several microwave-assisted protocols that have become integrated into the drug discovery research process in the biotechnology industry are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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