The effect of paraproteins on the erythrocyte sedimentation rate: a comparison between the StarrSed and TEST 1.
| Autor: | Raijmakers MT; Laboratory of Clinical Chemistry, Máxima Medical Centre, Veldhoven, The Netherlands. m.raijmakers@mmc.nl, Kuijper PH, Bakkeren DL, Vader HL |
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| Jazyk: | angličtina |
| Zdroj: | Annals of clinical biochemistry [Ann Clin Biochem] 2008 Nov; Vol. 45 (Pt 6), pp. 593-7. Date of Electronic Publication: 2008 Sep 09. |
| DOI: | 10.1258/acb.2008.008062 |
| Abstrakt: | Background: The principle of the erythrocyte sedimentation rate (ESR) as assessed by TEST 1 is different from that of Westergren-based methods. This could result in different influences on the tests by paraproteins. Methods: We investigated the effect of paraproteins on ESR readings by TEST 1 (y) and the StarrSed (x), a Westergren-based method, in 142 patients with paraproteinaemia. Agreement (Passing-Bablok) and bias (Bland-Altman) between methods was investigated and compared with that of a control population. Results: A poor agreement between the two methods was found in patients with a paraprotein (y = 0.67x + 3.3) in comparison with that of the control population (y = 0.96x + 0.2). Large differences between methods were present when ESR readings were >40 mm/hour, but clinical interpretation was similar in 90% of cases. Linear regression showed a concentration dependent influence of paraproteins on ESR readings by the StarrSed, especially for immunoglobulin class IgM. Conclusion: ESR readings by TEST 1 result in similar clinical interpretation for most subjects, but readings are less influenced by the presence of a paraprotein than those of a Westergren-based method. |
| Databáze: | MEDLINE |
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