| Autor: |
McComas CC; Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, S2227A, Collegeville, PA 19426, USA. mccomac@wyeth.com, Vu AT, Mahaney PE, Cohn ST, Fensome A, Marella MA, Nogle L, Trybulski EJ, Ye F, Zhang P, Alfinito P, Bray J, Johnston G, Koury E, Deecher DC |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Sep 15; Vol. 18 (18), pp. 4929-31. Date of Electronic Publication: 2008 Aug 22. |
| DOI: |
10.1016/j.bmcl.2008.08.060 |
| Abstrakt: |
Norepinephrine and serotonin play an important role in a wide variety of biological processes and are implicated in a number of neurological disorders. A novel class of 1-(3-amino-1-phenylpropyl)indolin-2-ones was designed and synthesized that displays potent norepinephrine reuptake inhibition while maintaining high selectivity (>100-fold) against the human serotonin and dopamine transporters. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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