Autor:	Rallidis LS; Second Department of Cardiology, University General Hospital, 'Attikon', Greece. rallidis@ath.forthnet.gr, Lekakis J, Panagiotakos D, Fountoulaki K, Komporozos C, Apostolou T, Rizos I, Kremastinos DT
Jazyk:	angličtina
Zdroj:	European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology [Eur J Cardiovasc Prev Rehabil] 2008 Oct; Vol. 15 (5), pp. 567-71.
DOI:	10.1097/HJR.0b013e32830774db
Abstrakt:	Background: There are few and conflicting data regarding the prognostic role of continued smoking in very young survivors of acute myocardial infraction (AMI) after the event. Design: We conducted a prospective study to evaluate the impact of smoking habits on long-term outcome in individuals who sustained AMI at the age of Methods: We recruited 147 consecutive patients who had survived their first AMI at the age of Results: The most prevalent risk factor at presentation was smoking (94.8%). Follow-up data were obtained by 135 patients (32+/-3 years old, 115 men). During follow-up 75 (55.6%) patients reported continuation of smoking. Forty-four (32.6%) patients presented cardiac events (three cardiac deaths, 30 acute coronary syndromes, and 11 revascularizations). Multivariable data analysis showed that persistence of smoking (relative risk=2.35, 95% confidence interval 1.5-5.25, P=0.03) and ejection fraction at presentation (relative risk=0.95, 95% confidence interval 0.91-0.98, P=0.008) were the only significant predictors of cardiac events after adjusting for various confounding factors. In addition, continuation of smoking was the most significant predictor of cardiac events during follow-up in our sample (i.e. had the lowest log-likelihood ratio as compared with ejection fraction or other covariates). Conclusion: Persistence of smoking is the most powerful predictor for the recurrence of cardiac events in patients with premature AMI.
Databáze:	MEDLINE
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