Accuracy of 18F-FDG-PET/CT for staging of oral squamous cell carcinoma.

Autor: Pentenero M; Oral Medicine and Oral Oncology Section, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. monica.pentenero@unito.it, Cistaro A, Brusa M, Ferraris MM, Pezzuto C, Carnino R, Colombini E, Valentini MC, Giovanella L, Spriano G, Gandolfo S
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2008 Nov; Vol. 30 (11), pp. 1488-96.
DOI: 10.1002/hed.20906
Abstrakt: Background: This study prospectively assessed 2-[F18]-fluoro-2-deoxy-D-glucose-positron emission tomography (18F-FDG-PET)/CT (PET/CT) in oral squamous cell carcinoma.
Methods: Twenty-three patients completed preoperative TNM staging (CT, MR, whole-body fusion imaging PET/CT). In patients who underwent surgical therapy (19 of 23), TNM staging based on PET/CT scan was compared with pTNM.
Results: PET/CT correctly staged 16 of 19 primary tumors (accuracy 84.2%, sensitivity 84.2%, positive predictive value 100%) and correctly ruled out bone invasion in 3 patients with false-positive results according to CT and/or MR. PET/CT incorrectly identified neck involvement in 5 of 15 patients (3 false positives, 2 false negatives) who underwent neck dissection (accuracy 66.7%, specificity 76.9%, negative predictive value 83.3%). False-negative cases showed a nodal size not exceeding 10 mm. One patient with a bronchial synchronous primary tumor was identified.
Conclusion: PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases.
((c) 2008 Wiley Periodicals, Inc. Head Neck, 2008.)
Databáze: MEDLINE
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