| Abstrakt: |
The aim of the investigation was to determine the existence and describe interconnection between the lipid metabolism disturbances and development of systemic inflammation. The work was carried out on rabbits in two series of experiments: in the first one, the model of inflammation was reproduced by means of intravenous injection of bacterial lipopolysaccharide. In the second one, the model of lipid disturbances induced by lipids enriched diet was reproduced. In both series of experiments, the indexes of inflammation and oxidative stress intensity, metabolism of lipids and lipoproteins, insulin sensitivity, blood lipoprotein proatherogenic and immunogenic modification were determined. The data obtained confirmed the existence of distinct direct links between investigated influences: during the primary induced inflammation we observed pronounced disturbances in lipid and lipoprotein metabolism, while under the primary induction of lipid disturbances the systemic inflammation and oxidative stress were developed. The connection between the action of both influences was greatly mediated by their ability to induce insulin resistance. There was also shown that the interrelation between these factors is the cause of blood lipoprotein proatherogenic and immunogenic modification, which is the main effector mechanism of atherosclerosis development and progression. |
