Bacillus Calmette-Guerin and interleukin-2 for treatment of superficial bladder cancer.

Autor: Cockett AT; Department of Urology, University of Rochester School of Medicine and Dentistry, New York., Davis RS, Cos LR, Wheeless LL Jr
Jazyk: angličtina
Zdroj: The Journal of urology [J Urol] 1991 Sep; Vol. 146 (3), pp. 766-9; discussion 769-70.
DOI: 10.1016/s0022-5347(17)37916-8
Abstrakt: A total of 22 patients with bladder cancer received bacillus Calmette-Guerin (BCG) and interleukin-2. Significant bladder tumor remissions were noted in 15 of 17 patients (88%). Of 5 patients with carcinoma in situ 1 was noncompliant and he died of carcinoma in situ. The other 4 patients are in remission. BCG alone was instilled in 22 additional patients with superficial bladder cancer. The remission rates were encouraging. Of the 22 patients 13 (59%) had remission of the bladder tumor. A half dose of BCG (60 mg.) is adequate when given weekly for 6 weeks. Maintenance therapy is important as noted in both of our clinical arms. BCG and interleukin-2 therapy results in a higher remission rate.
Databáze: MEDLINE