| Autor: |
Arias M; Department of Neurology, Complexo Hospitalario, Universitario, Santiago de Compostela, Spain. mariasg@meditex.es, Osorio X, Dapena D, Arias-Rivas S, Vázquez F |
| Jazyk: |
angličtina |
| Zdroj: |
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2008 Sep; Vol. 14 (8), pp. 1139-41. |
| DOI: |
10.1177/1352458508094642 |
| Abstrakt: |
Diagnosis of primary angiitis of the central nervous system (PACNS) is difficult in relation to variability in its clinical manifestations and absence of specific signs in neuroimaging. A young patient presented with a recurrent encephalopathic clinical course. T2 and fluid-attenuated inversion recovery-magnetic resonance imaging (FLAIR-MRI) showed hyperintense lesions in the cerebral white matter suggesting demyelination. Those lesions decreased or even disappeared after treatment with steroids and immunoglobulins. In echo gradient MRI (T2*-MRI), there were permanent cortical-subcortical petechial hypointense lesions (microhemorrhages). Definite diagnosis was established after cerebral biopsy. Intravenous cyclophosphamide was administrated with no new relapses in more than 18 months of follow-up. In a compatible clinical course, the finding of petechial hemorrhages in T2*-WI could play an important role in early diagnosis of PACNS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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