In vivo growth-inhibition of Sarcoma 180 by an alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill.

4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. -->
Autoři: Gonzaga ML; Department of Organic and Inorganic Chemistry, Federal University of Ceará, P.O. Box 12200, Fortaleza, Ceará, 60455-760, Brazil., Bezerra DP, Alves AP, de Alencar NM, Mesquita Rde O, Lima MW, Soares Sde A, Pessoa C, de Moraes MO, Costa-Lotufo LV
Zdroj: Journal of natural medicines [J Nat Med] 2009 Jan; Vol. 63 (1), pp. 32-40. Date of Electronic Publication: 2008 Aug 23.
Způsob vydávání: Journal Article; Research Support, Non-U.S. Gov't
Jazyk: English
Informace o časopise: Publisher: Springer Country of Publication: Japan NLM ID: 101518405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1861-0293 (Electronic) Linking ISSN: 13403443 NLM ISO Abbreviation: J Nat Med Subsets: MEDLINE
Imprint Name(s): Original Publication: Tokyo : Springer
Výrazy ze slovníku MeSH: Agaricus/*chemistry , Antineoplastic Agents/*pharmacology , Polysaccharides/*pharmacology , Sarcoma 180/*drug therapy, Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Cell Line ; Cell Line, Tumor ; Fungal Proteins/chemistry ; Glucans/chemistry ; Humans ; Male ; Mice ; Phytotherapy ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; Sarcoma 180/pathology
Abstrakt: Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different parts of the world due to its anticancer potential. This effect is generally attributed to its polysaccharides; however, the precise structure of these has not been fully characterized. To better understand the relationship between polysaccharide structures and antitumor activity, we investigated the effect of the intraperitoneally (i.p.) or orally (p.o.) administered alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide from A. blazei alone or in association with 5-fluorouracil (5-FU) in tumor growth using Sarcoma 180 transplanted mice. Hematological, biochemical, and histopathological analyses were performed in order to evaluate the toxicological aspects of the polysaccharide treatment. The polysaccharide had no direct cytotoxic action on tumor cells in vitro. However, the polysaccharide showed strong in vivo antitumor effect. Thus, the tumor growth-inhibitory effect of the polysaccharide is apparently due to host-mediated mechanisms. The histopathological analysis suggests that the liver and the kidney were not affected by polysaccharide treatment. Neither enzymatic activity of transaminases (AST and ALT) nor urea levels were significantly altered. In hematological analysis, leucopeny was observed after 5-FU treatment, but this effect was prevented when the treatment was associated with the polysaccharide. In conclusion, this polysaccharide probably could explain the ethnopharmacological use of this mushroom in the treatment of cancer.
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Substance Nomenclature: 0 (Antineoplastic Agents)
0 (Fungal Proteins)
0 (Glucans)
0 (Polysaccharides)
Entry Date(s): Date Created: 20080830 Date Completed: 20090401 Latest Revision: 20211020
Update Code: 20221213
DOI: 10.1007/s11418-008-0286-4
PMID: 18726068
Autor: Gonzaga ML; Department of Organic and Inorganic Chemistry, Federal University of Ceará, P.O. Box 12200, Fortaleza, Ceará, 60455-760, Brazil., Bezerra DP, Alves AP, de Alencar NM, Mesquita Rde O, Lima MW, Soares Sde A, Pessoa C, de Moraes MO, Costa-Lotufo LV
Jazyk: angličtina
Zdroj: Journal of natural medicines [J Nat Med] 2009 Jan; Vol. 63 (1), pp. 32-40. Date of Electronic Publication: 2008 Aug 23.
DOI: 10.1007/s11418-008-0286-4
Abstrakt: Agaricus blazei Murrill, a native mushroom of Brazil, has been widely consumed in different parts of the world due to its anticancer potential. This effect is generally attributed to its polysaccharides; however, the precise structure of these has not been fully characterized. To better understand the relationship between polysaccharide structures and antitumor activity, we investigated the effect of the intraperitoneally (i.p.) or orally (p.o.) administered alpha-(1-->4)-glucan-beta-(1-->6)-glucan-protein complex polysaccharide from A. blazei alone or in association with 5-fluorouracil (5-FU) in tumor growth using Sarcoma 180 transplanted mice. Hematological, biochemical, and histopathological analyses were performed in order to evaluate the toxicological aspects of the polysaccharide treatment. The polysaccharide had no direct cytotoxic action on tumor cells in vitro. However, the polysaccharide showed strong in vivo antitumor effect. Thus, the tumor growth-inhibitory effect of the polysaccharide is apparently due to host-mediated mechanisms. The histopathological analysis suggests that the liver and the kidney were not affected by polysaccharide treatment. Neither enzymatic activity of transaminases (AST and ALT) nor urea levels were significantly altered. In hematological analysis, leucopeny was observed after 5-FU treatment, but this effect was prevented when the treatment was associated with the polysaccharide. In conclusion, this polysaccharide probably could explain the ethnopharmacological use of this mushroom in the treatment of cancer.
Databáze: MEDLINE
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