[Association of pulmonar tuberculosis with HLA system antigens in Northeastern Mexico].

Autor:	Rojas-Alvarado Mde L; Departamento de Genética de Poblaciones y Bioinformática, Centro de Investigación Biomédica del Noreste, Monterrey, N.L., México., Díaz-Mendoza ML, Said-Fernández S, Caballero-Olín G, Cerda-Flores RM
Jazyk:	Spanish; Castilian
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2008 May-Jun; Vol. 144 (3), pp. 233-8.
Abstrakt:	Background: Genetic susceptibility to pulmonary tuberculosis (PTb) has been associated with the HLA (Antigens of the Human Leukocytes) system of the MHC (Major Histocompatibility Complex), mainly with HLA-DR and-DQ antigens. Based on this assumption we carried out a case control study to determine the association of PTb with the HLA-DR and-DQ antigens among a sample of patients attending a medical unit belonging to the Mexican Social Security System (IMSS). Methods: HLA system phenotypes from cases (n=50) and controls (n=417), were defined serologically using a complement dependent microlymphocytotoxic assay. B lymphocytes were obtained using immunobeads. The allele and haplotype frequencies were determined using the Arlequin version 3.01 computer software. Relative risk (RR) was calculated with the Epimax Table Calculator. Results: The alelles HLA-DR11(5), -DR16(2) and -DQ7(3) and haplotypes /DR11(5)-DQ7(3), /DR14(6)-DQS(1) and /DR16(2)-DQ7(3) had a higher frequency in cases than in controls (RR>1, p<0.05). The HLA-DR17(3) and DQ8(3) alelles and /DR17(3)-DQ2 and /DR4-DQ8(3) haplotypes had a higher frequency among controls than among cases (RR<1, p<.05). Conclusions: These results indicate an association between PTb with the HLA-DR and -DQ antigens in a Mexican sample. Our results are similar to those found in the international literature.
Databáze:	MEDLINE
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