| Autor: |
Zheng LH; Institute of Genetics and Cytology, Northeast Normal University, 130024 ChangChun, China. zhenglihua_108@yahoo.com.cn, Bao YL, Wu Y, Yu CL, Meng X, Li YX |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 2008 Dec 08; Vol. 272 (1), pp. 102-9. Date of Electronic Publication: 2008 Aug 13. |
| DOI: |
10.1016/j.canlet.2008.06.029 |
| Abstrakt: |
Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment. In this study, we established an in vitro multiple drug resistant HepG2 cell line (HepG2/ADM), and characterized its MDR. This model was used to screen potential candidate chemosensitisers from over 200 purified naturally occurring compounds extracted from plants and animals. Cantharidin was found to have a significant reversal on MDR in our model. Further, our results showed that Cantharidin could significantly inhibit P-gp (P-glycoprotein) expression, mRNA transcription, as well as MDR1 promoter activity. These results suggest that Cantharidin is a novel and potent MDR reversal agent and may be a potential adjunctive agent for tumor chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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