| Autor: |
Seravalli E; Foundation for Fundamental Research and Matter (FOM), Utrecht, The Netherlands. e.seravalli@tudelft.nl, de Boer M, Geurink F, Huizenga J, Kreuger R, Schippers JM, van Eijk CW, Voss B |
| Jazyk: |
angličtina |
| Zdroj: |
Physics in medicine and biology [Phys Med Biol] 2008 Sep 07; Vol. 53 (17), pp. 4651-65. Date of Electronic Publication: 2008 Aug 11. |
| DOI: |
10.1088/0031-9155/53/17/013 |
| Abstrakt: |
A two-dimensional position sensitive dosimetry system based on a scintillating gas detector has been developed for pre-treatment verification of dose distributions in hadron therapy. The dosimetry system consists of a chamber filled with an Ar/CF4 scintillating gas mixture, inside which two cascaded gas electron multipliers (GEMs) are mounted. A GEM is a thin kapton foil with copper cladding structured with a regular pattern of sub-mm holes. The primary electrons, created in the detector's sensitive volume by the incoming beam, drift in an electric field towards the GEMs and undergo gas multiplication in the GEM holes. During this process, photons are emitted by the excited Ar/CF4 gas molecules and detected by a mirror-lens-CCD camera system. Since the amount of emitted light is proportional to the dose deposited in the sensitive volume of the detector by the incoming beam, the intensity distribution of the measured light spot is proportional to the 2D hadron dose distribution. For a measurement of a 3D dose distribution, the scintillating gas detector is mounted at the beam exit side of a water-bellows phantom, whose thickness can be varied in steps. In this work, the energy dependence of the output signal of the scintillating gas detector has been verified in a 250 MeV/u clinical 12C ion beam by means of a depth-dose curve measurement. The underestimation of the measured signal at the Bragg peak depth is only 9% with respect to an air-filled ionization chamber. This is much smaller than the underestimation found for a scintillating Gd2O2S:Tb ('Lanex') screen under the same measurement conditions (43%). Consequently, the scintillating gas detector is a promising device for verifying dose distributions in high LET beams, for example to check hadron therapy treatment plans which comprise beams with different energies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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