A meta-analysis update: percutaneous coronary interventions.
| Autor: | Cecil WT; BlueCross BlueShield of Tennessee, 801 Pine St, 1E, Chattanooga, TN 37402, USA. bill_cecil@bcbst.com, Kasteridis P, Barnes JW Jr, Mathis RS, Patric K, Martin S |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of managed care [Am J Manag Care] 2008 Aug; Vol. 14 (8), pp. 521-8. |
| Abstrakt: | Objective: To update the most recent meta-analysis comparing percutaneous coronary interventions (PCIs) with medical therapy (MT) in patients having stable coronary artery disease (CAD) by including 2 new large trials that double the total number of patients. Study Design: Meta-analysis was used to update previous meta-analyses of PCIs in stable CAD. Eleven previously analyzed randomized controlled trials (RCTs) and 2 new RCTs were included. Methods: Summary estimates of relative risk (RR) are obtained by applying fixed-effects and random-effects models. Statistical tests for assessing between-study heterogeneity and biases are performed. Cumulative estimates and results from influence analysis are reported. Results: No difference between PCIs and MT alone was found for risk of mortality. There was a 12% increase in the RR of cardiac death or myocardial infarction (MI) associated with PCIs, as well as a 22% increase in the RR of nonfatal MI associated with PCIs. Cumulative analysis favored MT over PCIs as early as 1997, but recent study results have increased confidence in this finding. Because of heterogeneity between studies, no certain conclusions are drawn for the use of PCIs in preventing follow-up PCI or coronary artery bypass graft surgery. Conclusion: Recent RCTs comparing PCIs with conservative MT in stable CAD increase confidence in previous findings that the use of PCIs does not offer marginal benefit over that of the use of MT alone for mortality risk, cardiac death or MI, and nonfatal MI. |
| Databáze: | MEDLINE |
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