| Autor: |
Simioni AR; Departamento de Química, Laboratório de Fotobiologia e Fotomedicina, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil., Pelisson MM, Beltrame M Jr, Tedesco AC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2008 Jun; Vol. 8 (6), pp. 3208-15. |
| DOI: |
10.1166/jnn.2008.108 |
| Abstrakt: |
Nanostructured drug delivery systems (NDDS), such as liposomes, represent a growing area in biomedical research. These microheterogeneous media can be used in many biological systems to provide appropriate drug levels with a specific biodistribution. The photophysical properties of a silicon derivative of tribenzonaphthoporphyrazinato (Si-tri-PcNc) incorporated into liposome were studied by steady-state techniques, time-resolved fluorescence and laser flash photolysis. All the spectroscopy measurements performed allowed us to conclude that Si-tri-PcNc in liposome is a promising NDDS for PDT. The in vitro experiments with liposomal NDDS showed that the system is not cytotoxic in darkness, but exhibits a substantial phototoxicity at 1 microM of photosensitizer concentration and 10.0 J/cm2 of light. These conditions are sufficient to kill about 80% of the cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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