Common variable immunodeficiency in horses is characterized by B cell depletion in primary and secondary lymphoid tissues.

Autor: Flaminio MJ; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. mbf6@cornell.edu, Tallmadge RL, Salles-Gomes CO, Matychak MB
Jazyk: angličtina
Zdroj: Journal of clinical immunology [J Clin Immunol] 2009 Jan; Vol. 29 (1), pp. 107-16. Date of Electronic Publication: 2008 Aug 02.
DOI: 10.1007/s10875-008-9221-4
Abstrakt: Introduction: Common variable immunodeficiency (CVID) in horse patients is characterized by late-onset B cell lymphopenia or depletion, hypo- or agammaglobulinemia, impaired humoral response to tetanus toxoid vaccination, and recurrent fevers and bacterial infections.
Discussion: This study describes the clinical and immunologic findings of 14 affected horses (average age 10.7 +/- 4.4 years) of both genders (six females, eight males) and different breeds (eight Thoroughbreds, four Quarter Horses, one Warmblood, one Pony). Serial immunological testing in peripheral blood revealed persistent, severe B cell lymphopenia (mean 1.3 +/- 2.3% positive cells) in all patients. Serum IgG (range <200 to 800 mg/dL) and IgM (
Databáze: MEDLINE
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