| Autor: |
Thompson GR 3rd; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. thompsong2@uthscsa.edu, Wiederhold NP, Vallor AC, Villareal NC, Lewis JS 2nd, Patterson TF |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Oct; Vol. 52 (10), pp. 3783-5. Date of Electronic Publication: 2008 Aug 01. |
| DOI: |
10.1128/AAC.00473-08 |
| Abstrakt: |
We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
