Hepatitis C is less aggressive in hemodialysis patients than in nonuremic patients.

Autor:	Trevizoli JE; Hospital de Base do Distrito Federal, Secretaria de Estado de Saúde (SES), Brasília, DF, Brazil. jetrevizoli@terra.com.br, de Paula Menezes R, Ribeiro Velasco LF, Amorim R, de Carvalho MB, Mendes LS, Neto CJ, de Deus Macedo JR, de Assis F, Neves R
Jazyk:	angličtina
Zdroj:	Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2008 Sep; Vol. 3 (5), pp. 1385-90. Date of Electronic Publication: 2008 Jul 23.
DOI:	10.2215/CJN.01330308
Abstrakt:	Background and Objectives: The severity of liver disease among hepatitis C patients on hemodialysis is controversial. The aim of this study was to compare the clinical, biochemical, and liver histologic characteristics of hepatitis C virus (HCV) in hemodialysis patients and in those with normal renal function. Design, Setting, Participants, & Measurements: A case-control study was carried out with 36 HCV patients on hemodialysis and 37 HCV patients with normal renal function matched for gender, age at infection, and estimated time of infection. Results: HCV patients on hemodialysis had lower levels of alanine aminotransferase and lower viral load. Hepatic fibrosis was significantly higher in the patients with normal renal function (73%) than in hemodialysis patients (47.2%, P < 0.025); the same was observed for inflammatory activity (control group 59.5% versus hemodialysis patients 27.7%, P = 0.003). In addition, the risk of tissue inflammation was four times lower in hemodialysis patients (odds ratio = 0.23, P < 0.004), and severe inflammatory activity on biopsy was the only independent risk factor for fibrosis (P < 0.001). Conclusions: The lower biochemical and inflammatory activities observed in hemodialysis patients suggest that hemodialysis and uremia may have a protective role against progression of the disease caused by HCV.
Databáze:	MEDLINE
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