| Autor: |
Lesourd BM; Laboratoire d'Immunologie du Vieillissement, Faculté de Médecine Pitié-Salpétriére, 105 Boulevard de l'Hopital, 75013 Paris, France; Service de Médecine Interne Gériatrique, Hopital Charles-Foix, 7, Avenue de la République, 94200 Ivry, France., Laisney C, Salvatore R, Meaume S, Moulias R |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of gerontology and geriatrics [Arch Gerontol Geriatr] 1994; Vol. 19 Suppl 1, pp. 139-54. |
| DOI: |
10.1016/s0167-4943(05)80059-7 |
| Abstrakt: |
Aging is characterized by decreased T-cell functions partly related to increase of T-cell immature subsets. In carefully selected populations we explored influences of decreased nutritional levels and/or diseases on the appearance of T-cell immaturity in elderly persons. Decrease of nutritional status is associated in healthy elderly fitting the "SENIEUR" protocol with decreased mature T-cells (CD3+), (CD8+) and increased immature double-negative T-cells (CD2+CD4-CD8-). Diseased undernourished patients express the same variations in T-cell subsets plus decreased CD4+ and increased double-positive T-cells (CD2+CD4+CD8+). This seems to indicate that aging-associated immature T-cells in peripheral blood are generated at two different, thymic and extra-thymic sites of maturation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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