Statin pretreatment in experimental acute pancreatitis.
| Autor: | Almeida JL; Department of Gastroenterology, University of São Paulo Medical School, São Paulo, Brazil. josluizalmeida@yahoo.com.br, Sampietre SN, Mendonça Coelho AM, Trindade Molan NA, Machado MC, Monteiro da Cunha JE, Jukemura J |
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| Jazyk: | angličtina |
| Zdroj: | JOP : Journal of the pancreas [JOP] 2008 Jul 10; Vol. 9 (4), pp. 431-9. Date of Electronic Publication: 2008 Jul 10. |
| Abstrakt: | Context: Some authors have found beneficial effect of statins in certain inflammatory conditions, but the effect of statins on acute pancreatitis is not yet defined. Objective: The aim of this study was to evaluate the effect of simvastatin on an experimental model of mild and severe acute pancreatitis. Animals: One hundred and one Wistar rats with cerulein or taurocholate-induced acute pancreatitis were used in this study. Design: The rats were divided into two groups: Group I (n=51) received two previously i.p. injections (18+/-2 and 3+/-1 hours) of simvastatin (200 microg/kg) and Group II (n=50) received two previously i.p. injections of saline. Both groups were subdivided into two subgroups: mild pancreatitis (cerulein-induced; IA, n=10; IIA, n=10) and severe pancreatitis (taurocholate-induced; IB, n=41; IIB, n=40). Main Outcome Measures: The parameters evaluated were: pancreatic vascular permeability, tissue water content, histologic lesion, amylase serum levels in rats with mild pancreatitis (subgroups A); mortality rate, serum levels of IL-6, IL-10, amylase, pulmonary myeloperoxidase activity and ascitic levels of TNF-alpha in rats with severe pancreatitis (subgroups B). Results: Serum levels of IL-10 were significantly lower in the simvastatin-treated group as well as the myeloperoxidase activity. There was no significant difference in any of other studied parameters. Conclusion: Simvastatin appears to reduce inflammatory cytokines and pulmonary neutrophilic activation in the severe acute pancreatitis model, but there is no significant effect on survival curve, in spite of a clear trend towards a better survival in the simvastatin group. |
| Databáze: | MEDLINE |
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