| Autor: |
Jin Lee Y; Genome Center, University of California, One Shields Ave, Davis, California 95616, USA. yojlee@ucdavis.edu |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular bioSystems [Mol Biosyst] 2008 Aug; Vol. 4 (8), pp. 816-23. Date of Electronic Publication: 2008 Jun 10. |
| DOI: |
10.1039/b801810c |
| Abstrakt: |
Mass spectrometry has become the method of choice to detect and quantify the minute amounts of proteins at the genomic scale. It has recently been adopted for three dimensional structure analyses of proteins or protein complexes by chemically cross-linking their intact forms and analyzing the cross-linked pieces after digestion. This highlight provides an overview of the technology with a focus on advances in the last two years. This cross-linking mass spectrometry has a great potential to become a powerful tool to supplement current X-ray and NMR method of protein structure analysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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