| Autor: |
Palermo RD; School of Life Sciences, University of Sussex, Falmer, Brighton, UK., Webb HM, Gunnell A, West MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical Society transactions [Biochem Soc Trans] 2008 Aug; Vol. 36 (Pt 4), pp. 625-8. |
| DOI: |
10.1042/BST0360625 |
| Abstrakt: |
The EBNA 2 (Epstein-Barr nuclear antigen 2) transcription factor is essential for B-cell transformation by the cancer-associated EBV (Epstein-Barr virus) and for the continuous proliferation of infected cells. EBNA 2 activates transcription from the viral Cp (C promoter) during infection to generate the 120 kb transcript that encodes all nuclear antigens required for immortalization by EBV. EBNA 2 contains an acidic activation domain and can interact with a number of general transcription factors and co-activators. It is now becoming clear, however, that the regulation of transcription elongation in addition to initiation by EBNA 2, at least in part through CDK9 (cyclin-dependent kinase 9)-dependent phosphorylation of the RNA polymerase C-terminal domain, is likely to play a crucial role in the mechanism of action of this key viral protein. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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