The expression of thyroid hormone receptor isoforms in human astrocytomas.

Autor: Hwang SL; Division of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Lin CL, Lieu AS, Hwang YF, Howng SL, Hong YR, Chang DS, Lee KS
Jazyk: angličtina
Zdroj: Surgical neurology [Surg Neurol] 2008 Dec; Vol. 70 Suppl 1, pp. S1:4-8; discussion S1:8. Date of Electronic Publication: 2008 Jul 09.
DOI: 10.1016/j.surneu.2008.03.033
Abstrakt: Background: Thyroid hormone plays a major role in normal mammalian brain maturation and affects the development of astrocytes. The expression of TR isoforms has been studied in different neoplasias. Increasing evidence has suggested that aberrant expression of TR isoforms could be associated with tumorigenesis. However, little was studied about the expression of TR isoforms in human astrocytomas.
Methods: In this study, RT-PCR was used to examine the expression of human TR isoforms in 34 human astrocytoma samples.
Results: We compared the TR expression between low grade (WHO grade II) and high grade (WHO grade III and IV). The frequency of TRalpha1 or TRalpha2 expression significantly decreased with the grade of malignancy (P=.005 and P=.043, respectively). However, the frequency of TRbeta1 expression significantly increased with the grades of malignancy astrocytomas (P=.017).
Conclusions: Our study demonstrated for the first time that TR isoforms are indeed expressed in human astrocytomas. The expression of TR isoforms is correlated to the malignancy grading of astrocytomas. Our result provides insight into the potential use of hormonal therapy for brain tumors that overexpress or underexpress TRs.
Databáze: MEDLINE
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