| Autor: |
Medvetz DA; Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA., Hindi KM, Panzner MJ, Ditto AJ, Yun YH, Youngs WJ |
| Jazyk: |
angličtina |
| Zdroj: |
Metal-based drugs [Met Based Drugs] 2008; Vol. 2008, pp. 384010. |
| DOI: |
10.1155/2008/384010 |
| Abstrakt: |
A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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