| Autor: |
Luchessi AD; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av Prof Lineu Prestes, São Paulo, SP, Brazil. luchessi@icb.usp.br, Cambiaghi TD, Alves AS, Parreiras-E-Silva LT, Britto LR, Costa-Neto CM, Curi R |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 2008 Sep 04; Vol. 1228, pp. 6-13. Date of Electronic Publication: 2008 Jun 24. |
| DOI: |
10.1016/j.brainres.2008.06.057 |
| Abstrakt: |
Long-term memory, a persistent form of synaptic plasticity, requires translation of a subset of mRNA present in neuronal dendrites during a short and critical period through a mechanism not yet fully elucidated. Western blotting analysis revealed a high content of eukaryotic translation initiation factor 5A (eIF5A) in the brain of neonatal rats, a period of intense neurogenesis rate, differentiation and synaptic establishment, when compared to adult rats. Immunohistochemistry analysis revealed that eIF5A is present in the whole brain of adult rats showing a variable content among the cells from different areas (e.g. cortex, hippocampus and cerebellum). A high content of eIF5A in the soma and dendrites of Purkinje cells, key neurons in the control of motor long-term memory in the cerebellum, was observed. Detection of high eIF5A content was revealed in dendritic varicosities of Purkinje cells. Evidence is presented herein that a reduction of eIF5A content is associated to brain aging. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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