| Autor: |
Bautista DM; Department of Physiology, University of California, San Francisco, 600 16th St., San Francisco, California 94143-2140, USA., Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll RA, Julius D |
| Jazyk: |
angličtina |
| Zdroj: |
Nature neuroscience [Nat Neurosci] 2008 Jul; Vol. 11 (7), pp. 772-9. Date of Electronic Publication: 2008 Jun 22. |
| DOI: |
10.1038/nn.2143 |
| Abstrakt: |
In traditional folk medicine, Xanthoxylum plants are referred to as 'toothache trees' because their anesthetic or counter-irritant properties render them useful in the treatment of pain. Psychophysical studies have identified hydroxy-alpha-sanshool as the compound most responsible for the unique tingling and buzzing sensations produced by Szechuan peppercorns or other Xanthoxylum preparations. Although it is generally agreed that sanshool elicits its effects by activating somatosensory neurons, the underlying cellular and molecular mechanisms remain a matter of debate. Here we show that hydroxy-alpha-sanshool excites two types of sensory neurons, including small-diameter unmyelinated cells that respond to capsaicin (but not mustard oil) as well as large-diameter myelinated neurons that express the neurotrophin receptor TrkC. We found that hydroxy-alpha-sanshool excites neurons through a unique mechanism involving inhibition of pH- and anesthetic-sensitive two-pore potassium channels (KCNK3, KCNK9 and KCNK18), providing a framework for understanding the unique and complex psychophysical sensations associated with the Szechuan pepper experience. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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