Fibrosis in tubularized skin flaps in rats, using silicon catheters with two different degrees of flexibility. Experimental model.

Autor:	Passos AH; Division of Pediatric Surgery, College of Medicine of Marília, São Paulo, Brazil. ahrpassos@uol.com.br, Costa F, Marchese LT, Guimarães SA, Oreini WA
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2008 May-Jun; Vol. 23 (3), pp. 243-6.
DOI:	10.1590/s0102-86502008000300005
Abstrakt:	Purpose: Microscopically evaluate the intensity of fibrosis in tubularized skin flaps on the back of Wistar rats, using silicon molds with different degrees of flexibility. Methods: Twenty rats were submitted to three tubularized skin flaps on their backs. In two tubular flaps, we placed, as a mold, silicon catheters with different degrees of flexibility and removed them on the seventh day after the surgery. They were divided into two groups and euthanized, on the seventh and twenty-first days respectively after the surgery for the collection of the pieces, coloration with Masson tricromic, quantification of the area of each sample and comparison among the groups. Results: Fibrosis was less intense on the tubular flaps where a catheter was not used as a mold. No significant difference was verified among the pieces with the silicon catheters, but there was a tendency of less fibrosis on the tubules with the most flexible catheter. Conclusion: There was no significant difference among the two catheter types. Fibrosis was less intense in the flaps where the mold was not used.
Databáze:	MEDLINE
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