Single dose filgastrim in cytotoxic-induced neutropaenia in children.
| Autor: | Abdallah FK; Department of Human Pathology, College of Health Sciences, University of Nairobi, Nairobi, Kenya. |
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| Jazyk: | angličtina |
| Zdroj: | East African medical journal [East Afr Med J] 2008 Jan; Vol. 85 (1), pp. 30-5. |
| DOI: | 10.4314/eamj.v85i1.9603 |
| Abstrakt: | Objective: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. Design: A descriptive cross-sectional study. Setting: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. Subjects: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. Main Outcome Measures: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. Results: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). Conclusion: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group. |
| Databáze: | MEDLINE |
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