[Phospholipase A2, group IIa, as an earlier unknown immunohistological marker of cardiac myxoma].

Autor: Khaspekov GL, Sheremet'eva GF, Skamrov AV, Nechaenko MA, Vinnitskiĭ LI, Vlasik TN, Goriunova LE, Rutkevich NM, Peklo MM, Bibilashvili RSh
Jazyk: ruština
Zdroj: Arkhiv patologii [Arkh Patol] 2008 Mar-Apr; Vol. 70 (2), pp. 31-6.
Abstrakt: Phospholipase A2, group IIA, gene expression has been analyzed in primary heart tumors. High expression has been demonstrated through several ways: reverse-transcriptase chain polymerase chain, Northern blotting hybridization at the RNA level and immunoblotting, immunohistochemical assay at the protein level. Human cardiac myxoma exhibits highly positive phospholipase A2, group IIA, immunophenotype (100% positive cases). The immunophenotype is unique among human primary cardiac tumors. Phospholipase A2, group IIA, can be proposed as a tissue marker for pathological examination after heart tumor resection.
Databáze: MEDLINE