Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.

Autor: Arrighi RB; Department of Genetics, Stockholm University, Stockholm, Sweden., Ebikeme C, Jiang Y, Ranford-Cartwright L, Barrett MP, Langel U, Faye I
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Sep; Vol. 52 (9), pp. 3414-7. Date of Electronic Publication: 2008 Jun 02.
DOI: 10.1128/AAC.01450-07
Abstrakt: Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.
Databáze: MEDLINE