| Autor: |
Al-Agha OM; Department of Pathology, State University of New York,Downstate Medical Center at Brooklyn, USA. oalagha@healthcare.uiowa.edu, Igbokwe AA |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2008 Jun; Vol. 132 (6), pp. 1030-5. |
| DOI: |
10.1043/1543-2165(2008)132[1030:MFHBTP]2.0.CO;2 |
| Abstrakt: |
The precise nature and diagnostic concept of malignant fibrous histiocytoma (MFH) has been debated for years. Currently, a histiocytic lineage of the tumor cells is no longer favored. The nomenclature and classification of MFH and its subtypes have also been changed. The MFH pattern, especially that of storiform-pleomorphic variant, is viewed as a morphologic pattern shared by a number of sarcomas as well as by other nonsarcomas. Therefore, a diagnosis of MFH based solely on morphology is no longer acceptable and identification of a line of differentiation should be sought. A diagnosis of MFH should be made only for pleomorphic sarcomas in which no specific line of differentiation is discerned. Precise categorization of MFH-like tumors may require thorough sampling of the tumor and judicious use of immunohistochemistry and/or electron microscopy. Familiarity with the current terminology and classification of MFH and its subtypes is of paramount significance in the modern practice of pathology. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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