Cytokine profile in collagen-induced arthritis: differences between syngeneic and allogeneic pregnancy.

Autor: González DA; Research Unit, Hospital de La Candelaria, Santa Cruz de Tenerife, Canary Islands, Spain., de León AC, Moncholi CV, Díaz BB, Pérez MC, Aguirre-Jaime A, Coello SD, Hernández AG
Jazyk: angličtina
Zdroj: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2008 Jun; Vol. 57 (6), pp. 266-71.
DOI: 10.1007/s00011-007-7197-9
Abstrakt: Objective: To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA).
Methods: Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period.
Results: In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery.
Conclusions: Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).
Databáze: MEDLINE
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